The Apo E Gene Diet

The Apo E gene is the number one factor affecting how your body uses “The Big Three” food groups: carbohydrates, fats, and proteins.


We all have the Apo E gene (pronounced by saying each letter, A – P – O – E). This gene plays a key role in our body’s internal environment and influences the development of chronic disease, especially heart and Alzheimer’s disease.

The Apo E Gene Diet is not a diet in the usual sense of the word. We use the word “diet” to mean a series of specific recommendations for individual nutrition and other environmental factors, such as exercise and stress levels, to name a few.

quote openThe foundation of the Apo E Gene Diet is a nutritional plan that focuses on eating the optimal percentages of The Big Three food groups for your specifiquote closec Apo E genotype.


It is extremely important to eat the right balance of carbohydrates, fats and proteins for your specific Apo E genotype because it influences the possibility of developing certain diseases, as well as their severity.


Apo E 3/3, is found in approximately 64 percent of the population. It is considered the “neutral” Apo E genotype. Combinations that include either the Apo E 2 or Apo E 4 are considered “alternative” expressions of the more common Apo E 3 pairing. About 25% of the population have one or more of the E 4 genes and 12% have one or more of the E 2 genes. People with an Apo E 2 or 4 process foods differently from the Apo E 3s.

The specific pair of Apo E genes you inherited from your parents greatly influences your predisposition to certain illnesses, including heart disease, vascular dementia, Alzheimer’s disease, Parkinson’s disease, and cancer. For example, persons with the Apo E 4/4 genotype could have up to a 90% chance of developing a chronic illness such as Alzheimer’s disease. Maintaining an optimal diet and lifestyle for your particular Apo E genotype is known as a “gene-supportive environment” (GSE). Doing so can dramatically reduce your risk of developing these chronic illnesses. That’s why the Apo E Gene Diet was created.

quote openThe goal of the Apo E Gene Diet is disease prevention and a quote closehealthier life. 


There is a unique optimal combination of carbohydrates, fats, and proteins in the ideal diet for each of the six Apo E genotypes. Creating this optimal balance in your diet provides the foundation for your good health.

Most of the existing dietary recommendations are based on the assumption that one diet is appropriate for everyone. These diets fail to accomplish long-term weight loss or optimal disease prevention because we are not all the same. In reality, diet and exercise recommendations must be individualized, beginning with a person’s genetic foundation.


The Apo E Gene Diet focuses on an individual’s genetic recipe, creating dietary and exercise recommendations for each of the six possible Apo E genotypes.


No other program does this. In addition, the Apo E Gene Diet takes into account the whole person (physical, emotional, mental, and spiritual) in creating a gene-supportive environment that promotes a healthy life, free of chronic illness.


  1. First, read The Perfect Gene Diet by Pamela McDonald.
  2. After reading the book, you can make an informed decision as to whether you want to know your Apo E genotype. Finding your Apo E genotype is done through a simple cheek swab test or non-fasting blood test. 
  3. Once you know your Apo E genotype, follow the diet and lifestyle plan outlined in the book for your particular Apo E genotype. Personal guidance is also offered by phone or in person from our staff.


The Apo Gene Diet. Dr Seema Kanwal. Website